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Systematic Review: Comparative Effectiveness of Medications to ...
14 Sep 2009 by Heidi D. Nelson, Rongwei Fu, Jessica C....  
Conclusion: Three medications reduce risk for primary breast cancer but increase risk for thromboembolic events (tamoxifen, raloxifene), endometrial cancer (tamoxifen), or stroke (tibolone). Primary Funding Source: Agency for Healthcare ...
ANN INTERN MED: Most-Read Full-Text Articles - http://www.annals.org/

Drugs To Prevent Cancer? The NYT Misses The Devil In The Details
21 Nov 2009 by DrPeggyPolaneczky  
It cuts ovarian cancer by up to 80% and endometrial cancer by almost half. Like Tamoxifen and Raloxifene, the pill carries an increased risk of blood clots, a trade off many women are willing to make in return for prevention of ...
Better Health - http://getbetterhealth.com/

Clinics Turkey.com Health Advice and News - RECENT DEVELOPMENTS IN ...
5 Dec 2009
Raloxifene, too, has been shown to be cross-resistant to tamoxifen in Phase II trials of second-line treatment of advanced breast cancer (Buzdar et al., 1988) and appears to have equal efficacy to existing hormonal agents as first-line ... In these trials, no increase in endometrial carcinoma was seen. Breast cancer incidence was a secondary endpoint in these trials. These data have prompted the initiation of a further breast cancer prevention trial by the NSABP, ...
Clinics Turkey.com Health Advice and News - http://www.clinicsturkey.com/

Selective Estrogen Receptor Modulators
20 Nov 2009 by admin  
Raloxifene is administered without progestins because no endometrial or breast stimulation occurs. In fact, women treated with raloxifene experienced lower rates of endometrial and breast stimulation compared to placebo. ...
No SubHealth - http://www.nosubhealth.com/

Science-Based Medicine » Cancer prevention: The forgotten ...
16 Nov 2009 by David Gorski  
Tamoxifen is a selective estrogen receptor modulator (SERM) that antagonizes estrogen action in breast tissues but has partial agonist activity in bone and endometrium. Indeed, raloxifene, another SERM, is used primarily to prevent and ...
Science-Based Medicine - http://www.sciencebasedmedicine.org/ - References

Can your lifestyle really prevent cancer? | Washington Examiner
3 Dec 2009 by Mehment Oz  
It has serious downsides, too, including increasing a woman's chances of endometrial cancer, early menopause and blood clots that cause strokes. For these reasons, the American Cancer Society says tamoxifen's risks outweigh its benefits for two out of three ... Tamoxifen and a similar drug called raloxifene do cut risk, but so far haven't been proven to prevent deaths from breast cancer. Neither has finasteride, a drug that can reduce prostate cancer cases by 25 percent. ...
Washington Examiner Site Feed - http://www.washingtonexaminer.com/templates/rss

Breast cancer
30 Oct 2009 by janice drew - wai lana yoga # 1 fan  
It works like estrogen on bone, but it works like an "anti-estrogen" on breast tissue.34 Among high-risk women, raloxifene lowers their breast cancer risk about the same as tamoxifen does. Compared to tamoxifen, raloxifene's endometrial ...
Wai Lana Yoga - http://wailanayogafans.blogspot.com/

Systematic review: drug prophylaxis against breast cancer - NeLM
17 Nov 2009
All drugs were associated with adverse events: tamoxifen and raloxifene increased the risk of thromboembolic events by 4 to 7 per 1000 women per year (tamoxifen > raloxifene), tamoxifen increased the risk of endometrial cancer by about ...
NeLM - News - http://www.nelm.nhs.uk/en/NeLM-Area/News/

Pharmacy Education And Research .Com: Drug Research and Technology ...
18 Nov 2009 by Dr.Shruti Bhat  
In fact, tamoxifen and raloxifene boosted blood clots by 60 percent to 90 percent. Tamoxifen was also more likely than a placebo to lead to endometrial cancer and more likely to cause cataracts than was raloxifene. ...
Pharmacy Education And Research .Com - http://www.pharm-education.com/

Impact of Raloxifene or Tamoxifen Use on Endometrial Cancer Risk ...
28 Aug 2008 by DeMichele, Troxel, Berlin, Weber, Bunin,...  
Conclusion Raloxifene users had significantly lower odds of endometrial cancer compared with both tamoxifen users and SERM nonusers, suggesting a role for raloxifene in endometrial cancer prevention and individualization of SERM therapy ...
Journal of Clinical Oncology Current Issue - http://jco.ascopubs.org/

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