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Aminopterin « vetcetera
23 Mar 2007 by catmanager  
Renal FRs had higher affinities for aminopterin than for methotrexate at every pH tested. Although hydration and alkalinization decreased aminopterin toxicity (Glode et al., 1979), the efficacy of hydration alone in decreasing ...
vetcetera - http://catmanager.wordpress.com/ - References
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Methotrexate toxicity in kidney
1 Nov 2009 by Evelyn  
Methotrexate toxicity in kidney, rationing the studies in the pharmacopoeial programs settled their medicine specialties. Especially, just of famous hernia leaves on effects of residency limited on anthroposophical songs of new classes. ...
schmittdu6159 - http://schmittdu6159.blogspot.com/

Outcomes of methotrexate therapy
3 Dec 2009 by Administrator  
Previous studies in patients with either rheumatoid arthritis or psoriasis suggest that genetic variation across the methotrexate metabolic pathway might enable prediction of both efficacy and toxicity of the drug. ...
Medical Index - http://medicalindex.asia/
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Holllis-Eden to Present Interim Data From Its Phase I/II Clinical ...
12 Nov 2009
No disease flares or increased methotrexate toxicity were observed. Most adverse events were mild to moderate. Subject drug exposure remained dose proportional through the higher dose, and no change in methotrexate or Triolex ...
Drugs.com - Clinical Trials - http://www.drugs.com/clinical_trials.html
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Gene polymorphisms in folate metabolizing enzymes in adult acute ...
30 Sep 2009 by Ongaro, A., De Mattei, M., Della Porta,...  
Conclusions: Genotyping of folate polymorphisms might be useful in adult acute lymphoblastic leukemia to optimize methotrexate therapy, reducing the associated toxicity with possible effects on survival. Key words: gene polymorphisms, ...
Haematologica current issue - http://www.haematologica.org/

High-dose cytarabine plus high-dose methotrexate versus high-dose ...
29 Oct 2009 by Andrés JM Ferreri, Michele Reni, Marco...  
In patients aged 75 years and younger with primary CNS lymphoma, the addition of high-dose cytarabine to high-dose methotrexate provides improved outcome with acceptable toxicity compared with high-dose methotrexate alone. ...
The Lancet - http://www.thelancet.com/journals/lancet

DRUG INTERACTIONS ( CASE STUDIES RELATED TO ALTERED DRUG ...
22 Nov 2009 by udayasree datla  
c) METHOTREXATE - SULPHONAMIDES : Methotrexate is highly bound to plasma proteins. Salicylates and sulphonamides are capable of displacing it from the binding sites. So there is a potential for toxicity with methotrexate. ...
Pharmainfo.net - http://www.pharmainfo.net/
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Information on Vitamin A « The Truth Is Bliss
4 Dec 2009 by Baboon  
Vitamin D protects against the toxicity of Vitamin A as well as the other way around, so much so that studies show that up to 2300UI of pure natural Vitamin A per kilogram of body weight can be taken when there is enough D present along ... Liver disease, cystic fibrosis chronic diarrhea, alcohol abuse, smoking, birth control, chronic infection, stress, drugs that lower Cholesterol and bile production, and the drug methotrexate all will lower your Vitamin A levels within ...
The Truth Is Bliss - http://www.thetruthisbliss.com/ - References

Refolinon Injection 2 ml / 10 ml (leucovorin 3 mg/ml) - Revised ...
30 Nov 2009
Change to section 4.2 (Posology and administration) of Refolinon Injection. Inclusion of trimetrexate toxicity, trimethoprim toxicity, pyrimethamine toxicity and therapy after high-dose methotrexate. About this library entry ...
NeLM - SPC Changes - http://www.nelm.nhs.uk/en/NeLM-Area/Other-Lib-Updates/SPC-Changes/

Cytarabine plus methotrexate in primary CNS lymphoma - NeLM
21 Sep 2009
Adding high-dose cytarabine to high-dose methotrexate (MTX) may improve outcomes in patients with primary CNS lymphomas, according to a small controlled trial, albeit at the price of increased toxicity. Primary CNS lymphoma is uncommon, ...
NeLM - News - http://www.nelm.nhs.uk/en/NeLM-Area/News/
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