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Control of Wing Size and Proportions by Drosophila Myc -- Wu and ...
8 Nov 2009 by Wu, DC, Johnston, LA  
Control of Wing Size and Proportions by Drosophila Myc. D. Christine Wu* and Laura A. Johnston {dagger} ,1. * Department of Biological Sciences and {dagger} Department of Genetics and Development, Columbia University, New York, New York 10032 ... Here we examine the role of the growth regulator dMyc in this process during Drosophila wing imaginal disc development. We find that dMyc is expressed in a dynamic pattern that correlates with fate specification of different ...
Genetics recent issues - http://www.genetics.org/
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On Genetics: The genetic architecture of complex traits ...
12 May 2006 by Steve  
I am reminded of the graduate genetics course given by Michael Freeling that I sat in on while a postdoc at Berkeley (in 1984, while studying the effects of transposable element insertions on gene expression in Drosophila in Gerry Rubin's ... on growth in homozygous Growth9 individuals than [others]"). This kind of genetic interaction is precisely what any developmental geneticist would expect, yet breeders and population geneticists often cling to simple linear models. ...
On Genetics - http://ongenetics.blogspot.com/

PLoS Genetics: Genotype and Gene Expression Associations with ...
8 Jan 2010 by Timothy B. Sackton et al.  
Variation in suppression of bacterial growth is also determined in part by genetic variation in the expression of downstream components of the immune system that function to directly kill bacteria, despite finding no genetic variation in .... In Drosophila, linking genetic variation to phenotypic variation via transcriptional changes has proven difficult [10],[11]. The Drosophila immune system provides an ideal opportunity to examine the consequences of genetic variation ...
PLoS Genetics: New Articles - http://www.plosgenetics.org/?q=Save+Us+From+Berlusconi
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Developmental Cell - A Drosophila Insulin-like Peptide Promotes ...
14 Jan 2010
2 University College of London, Institute of Healthy Aging, GEE (Genetics, Evolution and Environment), University College London, Gower Street, London WC1E 6BT, UK. Corresponding author ... In Drosophila, growth is mediated by seven Drosophila insulin-like peptides (Dilps), acting through a canonical IIS pathway. During the larval period, animals feed and Dilps produced by the brain couple nutrient uptake with systemic growth. We show here that, during metamorphosis, ...
DEVELOPMENTAL CELL - http://www.cell.com/developmental-cell/current
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A Drosophila mutant of LETM1, a candidate gene for seizures in ...
21 Dec 2009 by McQuibban, GA, Joza, N., Megighian, A.,...  
We also show that DmLETM1 complements growth and mitochondrial K+/H+ exchange (KHE) activity in yeast deficient for LETM1. Genetic studies allowing the conditional inactivation of LETM1 function in specific tissues demonstrate that ...
Human Molecular Genetics - Advance Access - http://hmg.oxfordjournals.org/
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Waves of Adipose Tissue Growth in the Genetically Obese Zucker ...
22 Jan 2010 by sciencestaff  
We hypothesized that these genetic variants might increase the risk of T2D through regulation of alternative splicing or expression level of TCF7L2 in human adipose tissue. ... Here, we demonstrate that Drosophila larvae grown in low yeast food have strong defects in mitochondrial abundance and respiration activity in the larval fat body. This correlates with reduced expression of genes encoding mitochondrial proteins, particularly genes involved in oxidative ...
Untitled - http://sciencestage.com/resources/
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Proproliferative Functions of Drosophila Small Mitochondrial Heat ...
29 Jan 2010 by Wadhwa, R., Ryu, J., Gao, R., Choi, I.-K.,...  
DmHsp22 expression in human cancer cells increased their malignant properties including anchorage-independent growth, tumor formation in nude mice, and resistance to a variety of anticancer drugs. We report that the DmHsp22 interacts ...
Journal of Biological Chemistry current issue - http://www.jbc.org/

Evolutionary Medicine and the TNT phenotype | EvoS Blogs
6 Aug 2009 by Joseph Graves  
That is the idea that races of humans exist, and that they can be differentiated by genetic predispositions to particular diseases. An evolutionary perspective on cancer can resolve this confusion and at the same time offer fruitful avenues for .... Experimental work concerning the evolutionary theory of aging in invertebrate organisms (Drosophila) demonstrated that there were trade-offs in life history features that resulted from selection for delayed reproduction. ...
EvoS Blogs - http://evostudies.org/blog/

Cell - Distinct Protein Domains and Expression Patterns Confer ...
4 Feb 2010
Most axonal growth cones in the Drosophila ventral nerve cord initially extend toward the midline. Some stop or turn longitudinally before they reach the midline, but the majority continues across to the contralateral side. ...... Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons. Mitchell, K.J., Doyle, J.L., Serafini, T., Kennedy, T.E., Tessier-Lavigne, M., Goodman, C.S., and Dickson, B.J. (1996) ...
CELL - http://www.cell.com/current
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Journal of Biology | Full text | The THO complex as a key mRNP ...
27 Jan 2010
The first known component of THO, Hpr1, was identified through a genetic screen for hyper-recombinant mutants in Saccharomyces cerevisiae. Subsequent genetic and molecular characterization of mutants in which the hpr1 gene had been deleted (hpr1Δ ... Yeast THO null mutants are sick and slow growers and THO depletion has a negative effect on growth rate of human and Drosophila cell lines. THO is required for viability of the early mouse embryo and for postnatal survival, ...
Journal of Biology - Latest Articles - http://jbiol.com/
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